A Fur-regulated type VI secretion system contributes to oxidative stress resistance and virulence in Yersinia pseudotuberculosis

Abstract The type VI secretion system (T6SS) is a widespread protein apparatus deployed by many Gram-negative bacterial species to interact with competitor bacteria, host organisms, and the environment. Yersinia pseudotuberculosis T6SS4 was recently reported be involved in manganese acquisition; however, underlying regulatory mechanism still remains unclear. In this study, we discovered that regulated ferric uptake regulator (Fur) response ions (Mn 2+ ), negative regulation of Fur proceeded specifically recognizing promoter region Y. . Furthermore, induced low Mn oxidative stress conditions via Fur, acting as -responsive transcriptional maintain intracellular homeostasis, which plays important role transport for survival under stress. Our results provide evidence can enhance resistance virulence This study provides new insights into -dependent expands our knowledge mechanisms functions T6SS from